Name: Wei Hao
Major: Organometallic Chemistry
Research Interests: Organic Reaction Kinetics
E-mail: weihao@scripps.edu
Education：
2011.9 - 2016.6, Peking University, College of Chemistry, Ph.D.
Supervisors: Prof. Zhenfeng Xi, Prof. Wen-Xiong Zhang
Research Experience：
2021.7 - 2022.3, Peking University, College of Chemistry, Postdoctoral Fellow
Supervisors: Prof. Zhenfeng Xi, Prof. Wen-Xiong Zhang
2018.1 - 2021.7, The Scripps Research Institute, Department of Chemistry, Postdoctoral Fellow
Supervisor: Prof. Donna G. Blackmond
2016.7 - 2017.12, Cornell University, Department of Chemistry and Chemical Biology, Postdoctoral Fellow
Supervisor: Prof. Song Lin
Supervisor: Prof. Song Lin
Departure Destination:
The Institute of Chemistry, Chinese Academy of Sciences
Publicatons：
1. Wei Hao, Katherine L. Bay, Caleb F. Harris, Daniel S. King, Ilia A. Guzei, Michael M. Aristov, Zhe Zhuang, R. Erik Plata, David E. Hill, K. N. Houk, John F. Berry, Jin-Quan Yu, and Donna G. Blackmond, Probing Catalyst Speciation in Pd-MPAAM-Catalyzed Enantioselective C(sp3)-H Arylation: Catalyst Improvement via Destabilization of Off-Cycle Species.
ACS Catal. 2021, 11, 11040-11048.
2. Yazhong Huang†, Kyle W. Knouse†, Shenjie Qiu†, Wei Hao‡, Natalia M. Padial‡ Julien C. Vantourout‡, Bin Zheng, Stephen E. Mercer, Javier O. Lopez, Rohan Narayan, Richard E. Olson, Donna G. Blackmond, Martin D. Eastgate, Michael A. Schmidt, Ivar M. McDonald, and Phil S. Baran, A P(V)-Platform for Oligonucleotide Synthesis.
2. Yazhong Huang†, Kyle W. Knouse†, Shenjie Qiu†, Wei Hao‡, Natalia M. Padial‡ Julien C. Vantourout‡, Bin Zheng, Stephen E. Mercer, Javier O. Lopez, Rohan Narayan, Richard E. Olson, Donna G. Blackmond, Martin D. Eastgate, Michael A. Schmidt, Ivar M. McDonald, and Phil S. Baran, A P(V)-Platform for Oligonucleotide Synthesis.
Science, 2021 (accepted). (†, ‡Authors contributed equally.)
3. Yang Gao, David E. Hill, Wei Hao, Brendon J. McNicholas, Julien C. Vantourout, Ryan G. Hadt, Sarah E. Reisman, Donna G. Blackmond, and Phil S. Baran, Electrochemical Nozaki–Hiyama–Kishi Coupling: Scope, Applications, and Mechanism.
J. Am. Chem. Soc. 2021. 143, 9478-9488.
4. Yan-Qiao Chen, Sukriti Singh, Yongwei Wu, Zhen Wang, Wei Hao, Pritha Verma, Jennifer X. Qiao, Raghavan B. Sunoj, Jin-Quan Yu, Pd-Catalyzed γ‑C(sp3)−H Fluorination of Free Amines.
4. Yan-Qiao Chen, Sukriti Singh, Yongwei Wu, Zhen Wang, Wei Hao, Pritha Verma, Jennifer X. Qiao, Raghavan B. Sunoj, Jin-Quan Yu, Pd-Catalyzed γ‑C(sp3)−H Fluorination of Free Amines.
J. Am. Chem. Soc. 2020, 142, 9966-9974.
5. Wei Hao, Johannes H. Harenberg, Xiangyu Wu, Samantha N. MacMillan, and Song Lin, Diastereo- and Enantioselective Formal [3+2] Cycloaddition of Cyclopropyl Ketones and Alkenes via Ti-Catalyzed Radical Redox Relay.
J. Am. Chem. Soc. 2018, 140, 3514-3517.
6. Xiangyu Wu, Wei Hao, Ke-Yin Ye, Binyang Jiang, Gisselle Pombar, Zhidong Song, and Song Lin, Ti-Catalyzed Radical Alkylation of Secondary and Tertiary Alkyl Chlorides Using Michael Acceptors.
J. Am. Chem. Soc. 2018, 140, 14836-14843.
7. Qi Yang, Liang Liu, Yue Chi, Wei Hao, Wen-Xiong Zhang, and Zhenfeng Xi, Rhodium-Catalyzed Intramolecular Carbosilylation of Alkynes via C(sp3)–Si Bond Cleavage.
Org. Chem. Front. 2018, 5, 860-863.
8. Wei Hao, Xiangyu Wu, James Z. Sun, Juno C. Siu, Samantha N. MacMillan, and Song Lin, Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N‑Acylaziridines and Alkenes.
8. Wei Hao, Xiangyu Wu, James Z. Sun, Juno C. Siu, Samantha N. MacMillan, and Song Lin, Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N‑Acylaziridines and Alkenes.
J. Am. Chem. Soc. 2017, 139, 12141-12144.
9. Jianhao Yin, Qingyu Ye, Wei Hao, Shuaijing Du, Yucheng Gu, Wen-Xiong Zhang, and Zhenfeng Xi, Formation of Cyclopenta[c]pyridine Derivatives from 2,5-Disubstituted Pyrroles and 1,4-Dibromo-1,3-butadienes via Pyrrole-Ring One-Carbon Expansion.
Org. Lett. 2017, 19, 138-141.10. Wei Hao†, Junnian Wei†, Yue Chi, Patrick J. Walsh, Zhenfeng Xi, A DFT Study on Conversion of Aryl Iodides to Alkyl Iodides: Reductive Elimination of R–I from Alkylpalladium Iodide Complexes with Assesable b-Hydrogens.
Chem. Eur. J. 2016, 22, 3422-3429. (†Authors contributed equally.)
11. Wei Hao, Han Wang, Qingyu Ye, Wen-Xiong Zhang, and Zhenfeng Xi, Cyclopentadiene-Phosphine/Palladium Catalyzed Synthesis of Indolizines from pyrrole and alkenyl or aryl dibromides.
Org. Lett. 2015, 17, 5674-5677.
12. Wei Hao, Han Wang, Patrick J. Walsh, and Zhenfeng Xi, Combining Pd (π-allyl) Cp and PPh3 as a Unique Catalyst for Efficient Synthesis of Alkyliodo Indoles via C (sp3)–I Reductive Elimination.
12. Wei Hao, Han Wang, Patrick J. Walsh, and Zhenfeng Xi, Combining Pd (π-allyl) Cp and PPh3 as a Unique Catalyst for Efficient Synthesis of Alkyliodo Indoles via C (sp3)–I Reductive Elimination.
Org. Chem. Front. 2015, 2, 1080-1084.
13. Kunbing Ouyang, Wei Hao, Wen-Xiong Zhang, and Zhenfeng Xi, Transition-Metal-Catalyzed Cleavage of C–N Single Bonds.
Chem. Rev. 2015, 115, 12045-12090.
14. Wei Hao, Junnian Wei, Weizhi Geng, Wen-Xiong Zhang, and Zhenfeng Xi, Transfer of Aryl Halide to Alkyl Halide: Reductive Elimination of Alkylhalide from Alkylpalladium Halide Containing syn-b-Hydrogens.
Angew. Chem. Int. Ed. 2014, 53, 14533-14537.
15. Wei Hao, Weizhi Geng, Wen-Xiong Zhang, and Zhenfeng Xi, Palladium-Catalyzed One-Pot Three- or Four-Component Coupling of Aryl Iodides, Alkynes, and Amines through C-N Bond Cleavage: Efficient Synthesis of Indole Derivatives.
Chem. Eur. J. 2014, 20, 2605-2612.
16. Weizhi Geng, Chao Wang, Jie Guang, Wei Hao, Wen-Xiong Zhang, and Zhenfeng Xi, 1,2,3,4-Tetrasubstituted Cyclopentadienes and Their Applications for Metallocenes: Efficient Synthesis through Zirconocene- and CuCl-Mediated Intermolecular Coupling of Two Alkynes and One Diiodomethane.
Chem. Eur. J. 2013, 19, 8657-8664.
17. Weizhi Geng, Wen-Xiong Zhang, Wei Hao, and Zhenfeng Xi, Cyclopentadiene−Phosphine/Palladium-Catalyzed Cleavage of C−N Bonds in Secondary Amines: Synthesis of Pyrrole and Indole Derivatives from Secondary Amines and Alkenyl or Aryl Dibromides.
J. Am. Chem. Soc. 2012, 134, 20230-20233.
