研究室工作进展 May. 20th, 2018

杨琪  欧阳昆冰* 刘亮 席振峰*

Qi Yang, Kunbing Ouyang*, Liang Liu, and Zhenfeng Xi*

化学进展 2018, 30, 513-527.（综述，黄志镗先生诞辰九十周年纪念专辑）

Prog. Chem. 2018, 30, 513-527. (Review)

三甲基硅基（TMS）广泛存在于有机化合物中，并且在有机合成中有重要的应用。硅杂环化合物因其独特的理化性质而被广泛地应用于有机合成化学、材料化学和药物化学中。因此，将含有TMS基团的化合物直接用于硅杂环化合物合成的研究具有重要的意义。在有机合成化学中，碳-硅键的切断是一个非常重要的过程。通过化学计量的有机镁或有机锂等金属有机试剂对C(sp³)-Si键进行切断是碳-硅键活化的经典方法，然而该方法的反应条件苛刻，应用有限。而过渡金属催化的反应能够在较温和的条件下实现C(sp³)-Si键的切断，这为进一步官能团化C(sp³)-Si键提供了一种新方向，同时也是一种高效构建硅杂环化合物的新方法。目前过渡金属催化活化C(sp³)-Si键的研究主要集中在具有张力环或一些具有特定结构的底物中，对于催化活化惰性C(sp³)-Si键的研究仍然是一个具有挑战性的课题。本文结合我们自己的工作综述了近年来过渡金属催化的TMS中C(sp³)-Si键的方法。

The C(sp³)-Si bond in trialkylsilyl groups such as SiMe₃ is among the most frequently encountered C-Si bonds, because many compounds are substituted with trialkylsilyl groups. Silacycles, particularly siloles, have been recognized and extensively studied for their potential applications in organic synthetic chemistry, material science, and medicinal chemistry. The cleavage and applications of the C-Si bond is important in organic synthetic chemistry. However, classic methods require a stoichiometric amount of either organo-magnesium or organolithium reagent. The harsh conditions in these methods do not tolerate many functional groups, thus limiting the synthetic application of these approaches. Transition-metal-catalyzed cleavage of the C(sp³)-Si bonds would be ideal for overcoming the limitation. The process not only shows a new and unique entry to functionalize the C(sp³)-Si bond, but also presents a powerful method to synthesize diverse organosilanes. Up to now, the majority of successful examples, in which the strategy of transition metal catalyzed reactions was applied into activation of C(sp³)-Si bonds, has concentrated on the strained cyclic compounds and functionalized substrates. Hence, the activation of unactivated C(sp³)-Si bonds remains a challenging issue. This review article summarizes recent reports on transition-metal-catalyzed cleavage and synthetic applications of the C(sp³)-Si bonds. In addition, the organometallic reagent-promoted cleavage of C(sp³)-Si bonds is also presented for comparison.