Lu Research Group
Mar. 2022
In this work, we reported the unexpected water-assisted controlled ROP of ProNCA, which affords well-defined PLP as polyproline II helices in 2-5 minutes and almost quantitative yields. Well done, Yali!
https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr/nwac033/6535632
Mar. 2022
In this work, we reviewed the state-of-the-art progresses of α-helical polypeptides for biomedical applications, with a special emphasis on the manipulation of helix-to-coil dynamic transition, conformation-associated anti-biofouling coatings, cellular uptake regulation, and reducing immunogenicity of polypeptide-protein conjugates. Well done, Zhang Chong!
http://www.cjps.org/article/doi/10.1007/s10118-022-2688-2?pageType=en
Oct. 2021
In this work, we developed a moisture-tolerant method enabling the facile synthesis of various challenging amino acid N-carboxyanhydrides, which could eventually greatly facilitate polypeptide preparation. Well done, Ziyou!
https://www.nature.com/articles/s41467-021-25689-y
September 2021
Dr. Lu is a co-organizer of the Young Scholar Symposium and delivered an invited talk.
Dr. Wu, Dr. Xiong, and Dr. Tian each gave a poster.
Dr. Tian Ziyou received the RSC Polymer Chemistry Poster Prize
Ms. Lu Jianhua received the general Best Poster Prize.
Congratulations to all of them!
September 2021
A JACS paper published from our group in 2020 (Lu, J. H. et al. J. Am. Chem. Soc. 2020, 142, 3, 1217-1221; DOI: 10.1021/jacs.9b12937) was recognized and collected in the 2021 JACS Early Career Investigators Virtual Issue!
https://pubs.acs.org/page/jacsat/vi/early-career-investigator2021
June. 2021
Dr. Hu Yali and Dr. Wang Hao, Class of 2016, successfully defended their PHD theses in May 30th and will join Jiangsu Hengrui Pharmaceuticals Co Ltd.
Wang Gan and Zhou Haisen, Class of 2017, received their B.S. in chemistry. Gan will pursue his Ph.D. in NTU at Sigapore and Haisen will continue his PHD research in our group.
Hearty congratulations to all of them!
July. 2021
An intracellular delivery system for His-tagged proteins was developed by Haisen. This is an invited paper for the special issue on "Rising Stars" of Polymer Journal. Hiasen became the first undergraduate in our group to publish a first-author article. Congratulations to him!
https://doi.org/10.1038/s41428-021-00526-7
April. 2021
Dr. Xiong Wei, Dr. Wu Guangqi, Sun Jialing and Lu Jianhua attended the 32nd CCS Congress in Zhuhai!.
Dec. 2020
To mitigate the high immunogenicity of asparaginase (ASNase), we used rigid helical zwitterionic polypeptides to modify ASNase and formed an urchin-like conjugate.
This conjugate showed significantly reduced immunogenicity as compared to a similarly made PEG-ASNase conjugate.
This is a nice collaboration work with the Lymphoma team from Peking University Cancer Hospital & Institute.
https://www.sciencedirect.com/science/article/pii/S0142961220308528?via=ihub
Dec. 2020
In this paper, we developed a facile route to precisely synthesizing protein-polypeptide-polydisulfide(doxorubicin) conjugate for synergistic chemo-protein therapy.
https://www.sciencedirect.com/science/article/pii/S2666542520300436
